[munificent]

> It's essentially like localized steroids to just the joint- killing off the immune cells causing inflammation.

Are you confusing osteoarthritis with rheumatoid arthritis? I didn't think the pain of osteoarthritis had anything to do with the immune response. You've literally got bone rubbing against bone. It's not going to feel good.

[eig]

Both OA and RA involve some inflammation (-itis means inflammation). RA is more T cell driven inflammation (and clinically visible) while OA is more macrophage driven. Mechanical wearing still makes the joint unhappy at the cellular level- you just don’t see it big and red as a symptom like in RA.