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by cthalupa 267 days ago
PCSK9 inhibitors do not universally lower hsCRP but still reduce cardiovascular events.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4876179/

https://pubmed.ncbi.nlm.nih.gov/36779348/

MR studies on genetics show that LDL and Lp(a) are independent risk factors for cardiovascular events regardless of hsCRP

https://www.nejm.org/doi/full/10.1056/NEJMoa1109034

https://pmc.ncbi.nlm.nih.gov/articles/PMC5483508/

https://europepmc.org/article/med/20032323

https://journals.plos.org/plosmedicine/article%3Fid%3D10.137...

https://www.nejm.org/doi/full/10.1056/NEJMoa1604304

https://pubmed.ncbi.nlm.nih.gov/23083789/