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by dyauspitr 273 days ago
Isn’t this a largely solved problem after Alphafold?
2 comments

Should an entry in a field preclude other ones. I encourage you to apply reductio-ad-absurdum here. Should Pepsi exist if Coke does? Should C exist if Fortran does?
Maybe they've been working on it, but got scooped?
I don't think that's the case. The numbers in the paper suggest ~92% of the training data comes from pre-existing AI models, including AlphaFold, and they claim things like:

> We largely adopt the data pipeline implemented in Boltz-11 1https://github.com/jwohlwend/boltz (Wohlwend et al., 2024), which is an open-source replication of AlphaFold3

I believe the story here is largely that they simplified the architecture and scaled it to 3B parameters while maintaining leading results.