[thaw13579]

I reviewed the linked studies of folinic acid treatment in ASD, and they uniformly say that larger studies are needed before considering this as a widely available treatment. The main issues that need to be worked out are:

* who this applies to (some studies suggest genotype and autism subtype matter for getting positive outcomes)

* what the side effects are (12 week studies of <100 people are not enough to safely deploy this as a long-term treatment at scale)

* how this compares to behavioral treatment (ABA and sensory interventions have reliable positive outcomes as well)

I think there's a useful signal there, but we need to be cautious rolling things out at a national scale without bigger studies.