[bzbarsky]

That's possible. Assuming you use any retina apps, of course. I'm looking at the apps I'm using right now, and none would actually be making full use of the retina display on a retina mbp.

I guess if/when I ran iPhoto it might look jarring. If I weren't running it full-screen on its own desktop, of course.

All of which is to say that it really depends on individual usage patterns.