[tayl0r]

  "In fact, Fresco in the first truly responsive lightbox.
  Give the demonstrations a try to see what that means,
  make sure to adjust your screen size (or rotate your
  device)."

On OSX Chrome I resized my browser and all it seemed to do was scale the content. It didn't change any layouts or do any "magic"... How is this so special?

[cdmoyer]

On my iphone, clicking an image opened as a tiny thumbnail at the top right and I couldn't navigate to the other images. A lightbox that worke on desktop and mobile smoothly would be great. But this doesn't see to be it. (and even better, as others note, handled links and herfs nicely.)