Hacker News new | ask | show | jobs
by glp1guide 285 days ago
Do yourself a favor, and just take GLP1s instead (after talking to your health care professional). The research on the effects is plentiful, they're incredibly effective, and next year by next year you'll have very effective FDA approved (for weight loss) oral GLP1s to take.

Losing weight is almost solved at this point, I'd post links but at this point the substack I run is heavily paywalled -- the research is out there and not hard to find with a quick search.
1 comments
esseph 285 days ago
My wife started taking GLP1 2 1/2 years ago. She had to stop because it made her throw up every morning.

She hasn't been on it for 2 years.

She still throws up every morning.

(Yes, they've gone into her digestive tract multiple times with cameras. It still won't stop. Changes in diet, sleep, etc have had no impact. Etc.)

Maybe it's not for everyone.

link
glp1guide 285 days ago
That sounds like a terrible experience, sorry you and the wife went through that and somehow the negative side effects STILL persist. This is honestly the first case I’ve ever heard of such an adverse effect.

GLP1s are certainly not for everyone, and if she had that reaction on a starting dosage then it certainly is obvious stopping was the way to go.

That said, for the vast majority of people though, GLP1s are likely going to the key to living longer and carrying less weight (including into old age). At this point, the research is behind the drugs being useful for the vast majority of the population, and the literal millions of people taking these drugs do not seem to be running into such horrific side effects, especially ones that continue after stopping the drugs.

Would you mind sharing which GLP1 she was on? This actually sounds like something that should be more widely known. Throwing up forever is quite a crippling side effect, and since GLP1s are more recently considered primarily brain drugs, I wonder if it triggered a persistent chemical imbalance.

link
esseph 285 days ago
There are multiple class actions consolidating.

https://www.lawsuit-information-center.com/ozempic-gastropar...

link
glp1guide 284 days ago
Yeah weirdly enough they’re only taking NAION and gastroparesis cases. Do you know by any chance why that is?

The NAION link is tenuous (research was inconclusive, I have written about this before[0]) and gastroparesis is a known side effect.

This was a great chance to learn the name of the vomiting symptom though — will be looking more into “cyclic vomiting syndrome”

[0]: https://glp1.guide/content/glp1s-and-the-link-to-blinding-di...

link
esseph 284 days ago
> only taking NAION and gastroparesis case. Do you know why by any chance why that is?

No, sorry.

Yes, CVS. Not the brand :)

link