[andreareina]

The way that Sean Carroll says it is something along the lines of, the fundamental physics governing everyday life are understood. That is to say, we can solve for what an electron, proton, etc (or a collection of maybe a few dozen) are going to do in a particular experiment. The second and third generations of charged particles are excluded from the definition of everyday life, as are any other hypothesized particles because they require higher energy levels than are relevant. Explaining how the brain works is excluded as not being fundamental, though in principle a sufficiently advanced computer would be able to simulate it.

[glenstein]

Exactly, that's where my mind went too. I think people are tempted by a well-meaning skepticism to think that it's high minded to be skeptical of affirmative claims of knowledge, but it ends up throwing a very hard won model of everyday physics out the window.

I saw a very frustrating live "debate" between Dr Blitz (monikor of a really cool science communicator and irl PhD physicist) and a flat earther, where the flat earther essentially borrowed these arguments (eg observations aren't really predictive or generalizable or able to count in favor of specific theories, confirmed theories have no special status etc) to dismiss the evidentiary support of the earth being round. It's an intellectual car crash masquerading as a respectable position on scientific foundations.