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by mfld 307 days ago
Yes, most bioinformatics tools are the result of research projects.

However, the most common bioinformatics file formats have actually been devised by excellent software engineers (e.g. SAM/BAM, VCF, BED).

I think it is just very convenient to have text-based formats as you don't need any special libraries to read/modify the files and can reach for basic Unix text-processing tools instead. Such modifications are often needed in a research context.

Also, space-efficient file formats (e.g. CRAM) are often within reach once disk space becomes a pressing issue. Now you only need to convince the team to use them. :)