[pitpatagain]

> Maybe the lack of occult infections with shorter acting drugs makes everyone confident that they won’t happen with longer acting drugs?

Previous experience is definitely part of it. It's not just Truvada, this isn't the first long acting injectable prep. Cabotegravir (integrate inhibitor) was approved 4 years ago for this use and is given every two months, so there's already information from how that was studied, approved and what's happened with several years of actual use.