| > The cause of Parkinson's is not fully understood and a simple Google search Did you ask me if that is all I did? I picked that becasue it is easier for the layperson to understand. I apologize for being on the cutting edge of Parkinson's research. Maybe they have not cured it yet becasue science is so resistant to new paradigms. Yes, low dopamine causes the symptoms of Parkinson's (PD), but what is causing the low dopamine is the oxidative stress destroying the Dopamine neurons. You could have searched more about it before you reacted so strongly, but here you go: Rethinking Parkinson's disease: could dopamine reduction therapy have clinical utility?
https://pmc.ncbi.nlm.nih.gov/articles/PMC11319508/ and Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease https://pubmed.ncbi.nlm.nih.gov/38196001/ "Excessive dopamine in experimental models modifies proteins in the mitochondrial electron transport chain and inhibits the function. α-Synuclein and familiar Parkinson's disease-related gene products modify the expression and activity of monoamine oxidase. " and Does levodopa slow or hasten the rate of progression of Parkinson's disease? https://pubmed.ncbi.nlm.nih.gov/16222436/ and Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)
https://www.spandidos-publications.com/10.3892/ijmm.2018.340... Besides, if PD was caused by low Dopamine, why does l-dopa, which resolves symptoms, only work temporarily and makes the condition worse? The logical way to explain this is that Dopamine is the problem.
The clinical study failed to demonstrate any evidence of levodopa worsening early PD. However, the beta-CIT SPECT substudy indicates the opposite effect, namely that levodopa causes a more rapid decline in the integrity of the dopamine transporter located in the nigrostriatal nerve terminals in the striatum." > Claiming that "if we cared" we'd see that everything is caused by dopamine, I did not say that. But dopamine has a lot to do with learned behaviors so thanks. https://www.sciencedirect.com/science/article/pii/S235215462... Your response seems reactionary and filled with your own biases. |
You seem well informed, but it's difficult to take anyone so needlessly snarky and defensive seriously.