[madaxe_again]

No, on the fact that there are plenty of known variants which increase the chance of lung cancer quite dramatically - moreso than smoking.

It’s not just lungs - things like FAP make your chance of getting colon cancer in your lifetime near to 100%, regardless of how many ginseng enemas you have or whatever the hell else you do.

Variants like TP53 (Li-Fraumeni) or EGFR mutations have measurable, population-level impacts on cancer risk.

Genetics loads the gun. Being alive then pulls the trigger.

[menaerus]

> No, on the fact that there are plenty of known variants which increase the chance of lung cancer quite dramatically - moreso than smoking.

But didn't you just say that it is the genetics and not the radon and/or smoking? Can you give some examples of those "plenty of known variants" for lung cancer?

[madaxe_again]

EGFR, as mentioned - it’s the most common cause of lung cancer in East Asian women.

TP53, as also mentioned - gives you a >90% chance of cancer of any variety in a lifetime. 50% by age 30.

Smoking presents about a 20% lifetime risk - and that’s without adjusting for genetic predispositions like CHRNA3/5 which increase nicotine addictiveness and promote tumorigenisis, or BRCA2, or CHEK2, which diminish DNA repair capabilities.

[menaerus]

Quite strong claims. I would be interested to read more about those. Do you have any references you can point out? A quick research on EGFR and TP53 suggested they are more related to colorectal cancer and not the lung cancer.