[wizzwizz4]

Individual cases are interesting. For example, Wikipedia says this of E122:

> In the US, this color was listed in 1939 as Ext. D&C Red No. 10 for use in externally applied drugs and cosmetics. It was delisted in 1963 because no party was interested in supporting the studies needed to establish safety. It was not used in food in the US.

> Azorubine has shown no evidence of mutagenic or carcinogenic properties and an acceptable daily intake (ADI) of 0–4 mg/kg was established in 1983 by the WHO.

Wikipedia's article on E180 is a stub. Wikipedia's article on E105 says it's now banned in both the US and EU, but it doesn't say when it was banned: did the US ever approve it?