[Sparkle-san]

Cheat code was probably not the best term for it, I'll admit. I don't fault anyone for chosing to try GLP-1s and the cause of obeseity isn't particularly on the individual given the prevailance of ultra processed foods and car transportation in our society. That all being said, regaining most, if not all, the weight has been a historical issue around weight loss treatments because they're not durable. The way we're proceeding with GLP-1s feels short-sighted and potentially unethical if we're setting people up for rebound failure to line the pockets of big pharma.

[44520297]

Would you say the same about blood pressure medications, diabetes medications, cholesterol medications, thyroid hormone replacement, antidepressants, mood stabilizers, antipsychotics, anti-anxiety medications, immunosuppressants, DMARDs, corticosteroids, anticonvulsants, Parkinson’s medications, multiple sclerosis treatments, blood thinners, and heart failure medications? All of them set people up for rebound failure if they stop taking them for the chronic condition they started them for.

[Sparkle-san]

I wouldn't group those together at all for the sake the argument. Take antidepressants for example. We're at the point of reexamining if we actually understand the consequences of long term usage of them. My personal experience was that my long term usage definitely came with issues and it's taken me a few years to feel like my emotional range has returned to a stabe baseline after going off them. I likely would have been better off using them short term. Depressiom is also quite similar to obesity in the sense that helping people develop the durable non-medical interventions while being treated with drugs would go further than just treating them with drugs alone.

Contrast this with Parkinson's which is a neurodegenerative disease with no known non-pharmacutical treatments and even the pharmacutical ones lose effectiveness as it progresses as they only treat symptoms, not the disease itself.

[44520297]

> go further than just treating them with drugs alone

This is precisely what the FDA guidance contains: that GLP1s be mixed with lifestyle modifications.

[const_cast]

> That all being said, regaining most, if not all, the weight has been a historical issue around weight loss treatments because they're not durable.

Almost all diets are not durable or sustainable. This is not unique to weightloss drugs - most people who lose weight, regain it.