As Matt Levine would say: inefficacious cancer drugs sold in the American market would be egregious securities fraud[1] if the shareholders are not informed by company offices ahead of time. The resulting shareholder lawsuit may cost some managers their jobs. There is also the (minute) risk of getting Luigi'd by someone a state over, whose loved one they suspected to have gotten a bad batch and didn't get better.
1. "Everything is securities fraud" is a running series showing the breadth and depth of how shareholders exercise their rights in creative ways.