[Perenti]

In my experience as a medically complicated person, generics generally work, but may have different side effects, both in scale and style. One of the worst was a duloxetine generic that came on so hard and strong that I felt serontoninised.

My friend the John the Pharmacist explained that the binders etc can accelerate absorption. His advice was be careful the first two days of a new generic formulation.

I would assume the NHS (like the TGA here in Oz) looks _very_ carefully at the side-affect profile before they buy any particular generic. Government agencies tend to try not to poison voters.

[johnisgood]

I take dimethyl-fumarate, which is a serious medication for MS, but sadly ever since "Tecfidera" got withdrawn for some reason, I can only get a "shittier" generic. That said, side-effect profile appears to be the same, thankfully. All in all, I think they are "almost" identical, if not identical.

[hinkley]

I’ve had decent luck with slow release generics, but they go out of their way to make SR generics take a quarter of a human lifetime to come out after the original is available.