[seydor]

this is such an interesting problem. Imagine expanding the input size to 3.2Gbp, the size of human genome. I wonder if previously unimaginable interactions would occur. Also interesting how everything revolves around U-nets and transformers these days.

[pfisherman]

You would not need much more than 2 megabases. The genome is not one contiguous sequence. It is organized (physically segregated) into chromosomes and topologically associated domains. IIRC 2 megabases is like the 3 sd threshold for interactions between cis regulatory elements / variants and their effector genes.

[teaearlgraycold]

> Also interesting how everything revolves around U-nets and transformers these days.

To a man with a hammer…

[TeMPOraL]

Or to a man with a wheel and some magnets and copper wire...

There are technologies applicable broadly, across all business segments. Heat engines. Electricity. Liquid fuels. Gears. Glass. Plastics. Digital computers. And yes, transformers.

[SV_BubbleTime]

Soon we’ll be able to get the whole genome up on the blockchain. (I thought the /s was obvious)

[eleveriven]

Even just modeling 3D genome organization or ultra-long-range enhancers more realistically could open up new insights