[arthur2e5]

AM404 really is the metabolite that keeps giving. The central nervous system system effects were fun too, acting on cannabinoid receptors and/or TRPV1 channels -- so either stony or spicy.

[PaulHoule]

I can't say it ever made me feel high, but acetaminophen has been long shown to have significant behavioral effects

https://pubmed.ncbi.nlm.nih.gov/27217114/

https://pubmed.ncbi.nlm.nih.gov/32888031/

My primary care doc doesn't want me taking either NSAIDS or acetaminophen so when I get asked at the urgent care what I take for pain I say "Nothing".