[Spooky23]

The problem with your position is simple: where does it come from?

The legit path for compounded semaglutide is buying up Rybelsus, impacting the supply for diabetics. Compounding pharmacies are notoriously shady, and are likely using grey market materials from questionable sources.

[bevr1337]

> Compounding pharmacies are notoriously shady, and are likely using grey market materials from questionable sources.

Are they? Compounding pharmacies are common and boring. If someone hasn't yet used a compounding pharmacy then it's likely they're in very good health -- yay for them!

What's being described doesn't feel like an issue with compounding rather folks setting up shop to peddle questionable drugs.

[bickfordb]

Is there evidence that compounded Semaglutide from Hims pharmacies has harmed anyone?

[hammock]

Safe and effective. Side effects are very rare and are usually limited to soreness at the site of injection. Recommend everyone who is recommended semaglutide by a relevant authority, to get it. The obesity epidemic is a national security concern

[zdragnar]

I don't think the question was whether semaglutide was safe, but whether the version that Hims sells is safe. That includes things like being free from contaminants, stability of the compound, etc.

[Spooky23]

Hims just outsources fulfillment to a compounding pharmacy. Usually they add vitamin B-12 to make it "customized". Are they crushing rybelsus? Getting raw materials through some mysterious supply chain from Ukraine, China or Israel?

You have no idea.

On the flip, I think access to basic drugs for stuff like ED, hair loss, etc is fine. But they also do stuff like off-label anti-depressants, etc can potentially be dangerous... but at the same time, people are going to urgent cares and getting antidepressants with just more cost and friction.

[ryandrake]

> I don't think the question was whether semaglutide was safe, but whether the version that Hims sells is safe.

Don’t forget “effective” too. If you just make the bar “safety” then you are accepting sugar pills as medicine for whatever condition. You should need to prove both safety AND effectiveness.

[hammock]

Sugar is arguably more “effective” than it is “safe.” But I know you are referring to sugar pills not sugar diet

[hammock]

How would you even test for that?

[Der_Einzige]

Yup. And using it as the wonder drug it is, I.e women using it to get “beach bodies” should be celebrated and not stigmatized.

I want bodily autonomy and control. The right to experiment with weight loss drugs is analogous to the right to be trans or to not have your foreskin removed at birth.

It’s crazy that these drugs even have further benefits like anti addiction properties!

[DrillShopper]

> The right to experiment with weight loss drugs is analogous to the right to be trans or to not have your foreskin removed at birth

Both things the current administration is fighting against, so the metaphor is really apt.

There are a lot of trans people on HRT that DIY their meds, especially transfemmes, because estrogen is not a controlled substance.

[hammock]

Miracle drugs. I wouldn’t be mad if we made these injections required for entry into public schools or employment

[bitwize]

Semaglutide is linked to NAION, a "stroke" in the retinal blood vessels linked to a blood pressure drop there, typically when sleeping. I think I already have one of these in one eye. I DO NOT want to risk getting it in the other. Staying off semaglutide until it's really necessary.

[sizzle]

That’s a pretty bold claim, got a citation to back it up?

[bitwize]

https://pubmed.ncbi.nlm.nih.gov/38958939/

[jrflowers]

Can you give some specific examples of compounding pharmacies buying up Rybelsus or using grey market GLP-1

[Spooky23]

There’s a bunch of material out there including acknowledgment from the association of compounding pharmacies.

They are in general shady, and the Florida pharmacies are notoriously under-regulated. Guess where most of the online dick pill outlets do their compounding?

[Brian_K_White]

Why would this product be different from any other product?