[matthewowen]

You'll need to get a visa. As with getting a job in the USA if you're a UK citizen, it isn't as simple as just applying for and getting a job.

Your degree won't qualify you as a highly skilled worker, so unless you have other connections you're probably in for a long hard slog getting a suitable visa.

[001sky]

"Your degree won't qualify you as a highly skilled worker"

An Advanced UK-issued degree, relevant to the appointment, may be an exception. But absent that, the general rule on "expertise" ~= you are the only person in the EU with such. Alternatively, if your appointment is at "Board Level" (Ceo, Director, etc.) there is an exemption, so you may qualify as a "co-founder" (if such an opporunity were to arise).

The devil is in details, however. Granular and somewhat varying year-to-year.

[matthewowen]

I assumed from the original post that the degree was an undergraduate CS degree from the US.

[nickvanhoog]

Correct assumption.