[biophysboy]

Irreproducibility is not the same as fraud. In any case, I would support high-risk research - stuff that may not be repeatable - if it has a high direct ROI, economic spillover (USA has a big biotech/pharma ecosystem), and leads to cost savings (e.g. no more dialysis machines).

[1970-01-01]

Yes, exactly. Defund the junk science, the circles that are put around the results and called targets, and all the questionable research activity until merit has returned to scientific research and the vast majority of empirical studies can be replicated without p-hacking it.

[biophysboy]

Ehh.. I think you're overestimating how easy it will be to make science repeatable. Even if we perfectly execute experimental/statistical methods, biological experiments are not always going to be reproducible.

Edit: as a follow up (because I feel like I strawmanned you), I am just trying to say that p-hacking is not always malice or incompetence. Sometimes limited methods/theory miss confounding variables, sometimes labs lack resources, etc.