| Here's my regular Claude prompt: 5 bullet points, make sure I fully understand everything in 5 bullet points: (My deliberate buzzfeedification of the Internet) --- - Brain aging isn't linear - it follows an S-curve with key milestones: onset ~age 43, fastest decline ~age 61, then plateau. - Insulin resistance drives it - metabolic problems (high blood sugar) appear first in midlife, before vascular or inflammatory issues. - Neurons can't use glucose but could use ketones - gene analysis shows aging brain regions have high insulin-dependent transporters but also ketone transporters. - Ketones reverse aging effects, but only ages 40-60 - ketone supplements significantly helped younger/middle-aged brains but did nothing for 60+ year olds. - There's a critical intervention window - the 40s-50s appear to be when neurons are stressed but still saveable, suggesting early metabolic treatment could prevent dementia. |