[snibsnib]

I'm not an expert in pharmaceutical chemistry, but this looks like a series of relatively complex and low yield reactions. Would it be likely that this would push the price of this product beyond what is reasonable for a general use drug?

[maxerickson]

The starting point is ~free (like 2 or 4 cents retail per dose for generic in the US). Given my relatively light usage of pain drugs, I would certainly pay 10x that for reduced toxicity.

And then it isn't necessarily the case that the identified reactions are the most cost effective available.

[toast0]

If you have light usage, do you need reduced toxicity?

Acetaminophen's effective dose is pretty close to the dangerous dose, but I would take light use to mean you take something maybe once a month max and only a single dose (or maybe even just one pill when the dose is two pills). At that level of use, I don't think you're at risk of anything.

Otoh, if the title is accurate and it can be more effective at pain release and less damaging to the liver, that would be great for people who experience pain frequently.

[w10-1]

If it makes it to market at a high price, it wouldn't compete directly but be targeted to those at risk of toxicity.