[vegadw]

Good cables (Though maybe not silver, that shouldn't matter much), ironically, actually do make an audible difference. Just good, oxygen free, low capacitance cable is what you want. Because guitars are high impedance and how tone pots are wired and the input your plugging into (Be it a pedal, amp, or interface) also usually being high impedance, how much capacitance (Not resistance, not really) matters a lot in where the natural cutoff of the passive LRC circuit your making. Go listen to some demos on Youtube just swapping cables, it matters.

It does mostly matter for noise though, yeah.

Also, active guitars largely get around these problems, as do low-impedance pickups.

I find it weird that people chase all these different pickups and sounds instead of just getting a modern, active, flat-response pickup (See Cycfi's Nu & Spectra series) and EQing and compressing to the response they want.