Hacker News new | ask | show | jobs
by opwieurposiu 401 days ago
If you like Mitochondria stuff, This book about the Krebs cycle and how it was discovered is pretty good: https://nick-lane.net/books/transformer-the-deep-chemistry-o...

The short answer is: First you have to murder a pigeon to extract fresh breast muscle cells. Then you put those cells in a manometer which uses columns of water to measure respiration via tiny changes in gas volume. From there you can add various things like citric acid and see how that affects respiration.

So figuring out mitochondria required murdering a large number of pigeons. Their breast muscles have some of the highest rates of respiration known, many times better then ours.

Reading this book inspired me to attempt to improve my mitochondrial health. So far the only stuff that seems to make a difference is NAD+ and Creatine.

4 comments

> First you have to murder a pigeon to extract fresh breast muscle cells.

Tom Lehrer would approve!

"We'll murder them all amid laughter and merriment, except for the few we take home to experiment."

https://www.youtube.com/watch?v=yhuMLpdnOjY

You’ve cursed me to play the countries of the world song in my head all day, again.
How did you measure your mitochondrial health, short of extracting fresh breast muscle cells and putting them in a manometer?
Personally I inherited a mitochondria disease (LHON), so I'll be able to tell if mine becomes bad because I'll go blind.

Can't recommend you do this though.

I do group fitness classes, like CrossFit, body combat, spin class. When you have a room full of people all doing the same thing you can quickly tell which things you are above or below average at. Not very scientific perhaps but this is my current strategy.

For me I am below average at endurance, so that is where I assume the mitochondria come in.

That's the clever bit - you extract them from pigeons instead!
+1

Also supplementing with NAD+ and creatine for this reason. I also do PQQ and CoQ10 to de-bottleneck other phases of the Krebs.

have you tried zone-2 training? https://www.youtube.com/watch?v=-6PDBVRkCKc