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I’ve been doing my ‘side’ project as my day job for 5 years, 10 productive hours a day, 7 days a week. Sunday is dedicated to side side projects for experimental ideas that are not on the critical path.

When working a normal job I could only work part time due to burnout that I later found out was in reality ME/CFS. After a Covid vaccine injury (long covid) I had to pause work for a few years while I found a way to treat it. Once treated I elected to work on my side project even though I make much less money as I considerer the regular workforce to be highly dysfunctional and liable to cause me to relapse into a fatigued state.

> burnout that I later found out was in reality ME/CFS

In my experience, burnout is really just a subconscious realization that what you're doing is just not worth doing, even for large amounts of money, and it manifests itself in fatigue or pain, because your mind is trying to stop you.

100% not true in my case and probably not true in the generally case, it’s a common misattribution. The cause of mine is hEDS which has ME/CFS as a comorbidity. I’ve done a WGS and found that I have 2 TNXB SNPs. By my math a lot of ‘burnout’ especially in tech is related to TNXB or CYP21A2 SNPs. The treatments that I take specifically targets IL-1B cytokines that are linked to brain fog.

I was able to predict that I had these SNPs before taking the WGS test and once confirmed able to divise a treatment that worked. The probability of that happing by random chance is incredibly small.

myth2018 399 days ago

I'm going through a similar investigation. EDS + ME/CFS are the main suspects. Could live with the symptoms for very long, but they got too severe after covid (otherwise I would probably still be living with them).

Is the treatment working out well for you?

I’m pretty much back to 100% I just get the occasional slump but I can’t be sure that isn’t from working too hard.

For the IL-1B I take high doses of D3, TUDCA, and DIM. For the dysautonomia aspect I take Low Dose Naltrexone, a lower dose of modafinil in the morning and amitryptiline at night. I prefer weaker psychopharmacology ligands as it’s preferable to work with the natural rhythms of the body instead of fighting them.

I have a strict near zero sugar diet that’s high in kale. I take a low dose of semaglutide (ozempic) which has been one of the best meds I’ve tried. I make sure I get enough UV exposure. I’ve done Test Cyp and Ipamorelin/ModGRF and they do help a lot but I stopped taking them when semaglutide worked so well. I highly suspect people with hEDS are highly sensitive to semaglutide and should start and stay on much lower doses (1/10th) otherwise they’re near guaranteed to have a bad time.

I’m mostly interested in the TNXB subtype of hEDS which seems to have some weird comorbidities, like an intolerance to noise, a touch of ADHD, obstinate personality, difficulty falling asleep, local and general anesthetic resistance, and an unusually high IQ. There is an unusual reaction to medications with most medications working less than expected.

A good list of comorbidities that could help make a self diagnosis; https://ohtwist.com/about-eds/comorbidities

myth2018 399 days ago

Glad to hear you are well. Also because that gives me some more hope.

> which seems to have some weird comorbidities

I'm a bit shocked by your list of comorbidities. Not only yours, but also the one you linked to. MCAS is currently among my most pressing concerns, although it seems to be getting under control with H1 and H2 antihistamines + cromoglycate. An anti inflammatory diet also helps, even though I'm struggling to stay completely away from sugar. The psychiatric part calls my attention. I also present some traits of ADHD and ASD, although not enough to complete a diagnosis. Twenty years ago I joined mensa at the 99th percentile, but I do believe my IQ has decreased significantly since then. I can't even remember the last time I had, in my adulthood, my mind as functional as I used to have in my teenagehood, even before covid and the aggravation of the symptoms.

Out of your list, the only item I couldn't relate with were the medications working less than expected. In my case, I usually have stronger effects, both therapeutic and side ones. That happens with vaccines too. However, last weekend I took one for Influenza and the side effects were barely noticeable for the first time in my adult life -- I hope that's a result of the MCAS treatment.

Maybe you're right, what do I know? I don't have a PhD in this field. Just relating what I've seen in myself and others throughout my life.

Certainly an understandable position. The information I'm talking about is very modern as affordable high quality WGS are a recent innovation and news of the implications has not yet spread very far. It's a good time to revisit old superstitions.

On the other hand, the latest research and innovations are often gravely harmful but touted as safe and helpful for a long time by the experts, like lobotomies.

hollerith 399 days ago

WGS == whole genome sequencing

ChrisMarshallNY 399 days ago

In my case, I didn't know I was burned out, until after I was -literally- forced out of the industry.

I was really pissed off, for a while, but these days, I have zero desire to return to the Rodent Rally. I have been talking with a friend about a possible effort to create an altruistic organization. I have a couple of bored, rich, retired friends. May not go anywhere, but ya never know...

datameta 399 days ago

I think what you're describing is well encapsulated by a term I heard a few days ago - boreout.

I think the difference is that burnout can even be for things you're excited about and want to do, but subconsciously don't want to do for other reasons, e.g. the task/project goes against your ethics but you're pushing past that anyway, so your mind tries to stop you through stopping your body, e.g. fatigue or pain.