Personally, I prefer double vertical monitors (better for coding). But, when you've got 8, I think it's safe to say you can pretty much set them up however the hell you want.
What do you use to get sub-pixel anti-aliasing (aka ClearType) in portrait mode?
The higher-res anti-aliasing is the only thing that got me to switch from CRTs. I've tried portrait mode for similar reasons, but the loss of quality leaves me looking at pixels instead of characters or words.
Additionally, while LCDs are same-color horizontally, it changes faintly vertically. But since your eyes are also horizontal, there is no difference noted. When you turn the monitor vertically, though, there is a bit of color/differential/refraction to the different eyes. This drives me nuts.
The higher-res anti-aliasing is the only thing that got me to switch from CRTs. I've tried portrait mode for similar reasons, but the loss of quality leaves me looking at pixels instead of characters or words.