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by DrScientist 402 days ago
Bear in mind that they intentionally choose something that was soluble - ie the easiest thing possible. So it's doesn't mean everything is now solvable.

For example it's no coincidence this is a liver disease as basically almost everything you inject in the bloodstream ends up concentrating in the liver by default - if you needed to target another organ with your LNP it would be much harder. Most of the time people are trying to stop stuff accumulating in the liver!

The liver has other special properties that are helpful as well.

Having said all that - it is still a massive achievement.

> That is one of the most incredible things I have ever read.

Biology is incredible - and you can do incredible things if you leverage it.

1 comments

> that was soluble

solvable

soluble has two meanings.

- able to dissolve in solvent

- able to be solved.

Is the second meaning archaic?
How old does it need to be to be archaic?

Here is a use in the title of a quite famous popular science book from the 1960's.

https://www.routledge.com/The-Art-of-the-Soluble/Medawar/p/b...

Huh, TIL!