It’s not that simple.
And if we're talking about memory bugs (which we were up to now), then definitely no.
But run0 is new C code anyway so I don't see how your claim is relevant.
He was comparing to "normal" sudo, but sudo-rs have the same problems he highlighted anyway
run0 does not (and instead relies on systemd).
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To answer your next question: setuid, while historic, is a bit weird, and is disabled in some environments, e.g. NoNewPrivileges.
If your bar is “I’ll tolerate such crap”, you may as well run your desktop session as root.