Which use cases? I use Brave, which has a built in toggle to disable 3rd party cookies, which I have set to default, and at least my experience of 'the entire internet' works fine.
embedded iframes that need to authenticate logins but don't trust the parent domain to store the login data there is a problem. You can somewhat work around it with the Storage Access API if that browser supports it (brave doesn't), but it does mean every embed requires a click by the user first before it works properly