Clojure code ends up using a lot of reflection if you're doing generic Java interop. Most code destined for the GraalVM will add `(set! warn-on-reflection true)` and get repl warnings and you can set type hints accordingly.
My understanding is GraalVM's JIT keeps some optimizations for the enterprise edition, and is otherwise comparable to Hotspot, with some niche exceptions. I'm not sure "many" would benefit without paying.
I vaguely remember using it about 10 years ago for work, can't remember what for, or anything about that situation, but the one takeaway that I do remember is that it was neat and innovative, but ultimately not good enough to overthrow whatever we were using instead.