[Qem]

> We are very far from having a full single user graphics workstation in CPython, even if those JITs aren't perfect.

Some years ago there was an attempt to create a linux distribution including a Python userspace, called Snakeware. But the project went inactive since then. See https://github.com/joshiemoore/snakeware

[pjmlp]

I fail to find anything related to have a good enough performance for a desktop system written in Python.

[homarp]

Sugar is built with python

https://github.com/sugarlabs/sugar