[mobilejdral]

Tying this to APOE, specifically e4 which has an increased requirement for choline and when choline levels are low there can be a metabolic push that leads to elevated PHGDH activity and consequently, increased serine synthesis. That is a neat connection and maybe why when we study choline supplements we see positive results.

https://www.sciencedirect.com/science/article/pii/S000291652...

[pedalpete]

That is super interesting, as is the relationship between choline and sleep. With restorative sleep function, and specifically slow-wave activity, considered to be a significant driver of AD.

https://www.jarlife.net/3844-choline-sleep-disturbances-and-...

[mobilejdral]

And then this ties to estrogen, HRT is known to reduce the risk of dementia/AD (https://pmc.ncbi.nlm.nih.gov/articles/PMC10480684/).

PEMT (phosphatidylethanolamine N-methyltransferase) is what makes choline in the body, but it depends on estrogen.(https://pmc.ncbi.nlm.nih.gov/articles/PMC3020773/)

[pedalpete]

Yeah, part of my work is in dementia with slow-wave sleep enhancement, and we're putting together a menopause study hopefully to start in 2026.

[xlbuttplug2]

> In conclusion, our findings suggest that moderate dietary choline intake, ranging from 332.89 mg/d to 353.93 mg/d, is associated with lower odds of dementia and better cognitive performance.

Gemini tells me that amounts to ~850mg of alpha GPC or ~1900mg of citicoline. Eggs it is then.

[criddell]

How are you going to check Gemini’s math on that?

Claude tells me that’s 4-5 eggs per day or 5x150 mg alpha gpc capsules.

The eggs would be a lot more expensive in both time and materials plus most egg farms seem cruel (especially male chick killing)… I’m leaning towards alpha gpc supplements.

[xlbuttplug2]

> How are you going to check Gemini’s math on that?

Gemini used 40% choline by weight for alpha GPC and 18% for citicoline, which seems to check out with other sources.

> I’m leaning towards alpha gpc supplements.

I haven't looked into the studies recently, but there have been some negative findings with alpha GPC supplementation[1]. May be worth a gander.

[1] https://examine.com/supplements/alpha-gpc/#what-are-alpha-gp...

[criddell]

Eggs are safe as long as you limit yourself to one medium egg per day.

https://pubmed.ncbi.nlm.nih.gov/38733921/

Does a 100% safe and effective source of choline exist? Maybe a combination of eggs and supplements are the way to go?

[xlbuttplug2]

This stuff goes over my head, but perhaps one can take something to lower TMAO (I see EVOO, allicin, resveratrol, PQQ from a cursory search) to offset choline supplementation. This is assuming TMAO is the cause of increased disease risk and not just a biomarker.

[j45]

wow, thanks for sharing.