with Puny Inform6 or limiting Inform6, yes. If not, it's suicidal, even for v3 games.
But, from Amiga and Atari machines, most v5 and v8 games if not all will run great.
You would probably do better on 8-bits by using ZIL which is actually feasible these days thanks to ZILF (and the leaked ZIL source code of the original Infocom games to look at).