[raincom]

If you treat humans as biological machines, signaling system (hormones, endocrine system) is very important. When signaling system is messed up, your CI/CO model with self-control doesn't work at all. Signals need to be fixed.

[tekla]

So? That doesn't disprove the premise of CI/CO. CI/CO is the notion that humans exist in the physical world and thus obey the laws of thermodynamics.

[raincom]

CI + self-control or will --> CO (that's the hypothesis sold by many)

CI + hormones --> CO (that's an alternative hypothesis)