[yarnover]

It has happened in plants over and over again.

[echelon]

Gene dose increases in plants lead to bigger vegetables and fruiting bodies. We've taken advantage of this during domestication of several species.

Gene dose increases in animals lead to total dysfunction and death in embryonic development.

[kjkjadksj]

There are species of fish that have gone through whole genome duplication.

https://www.nature.com/articles/s41559-023-02299-z#:~:text=P...

[eimrine]

Dosis sola facit venenum?

[dekhn]

dose is such a weird term for "copies"

[flobosg]

It’s quite… historical.

[echelon]

https://en.wikipedia.org/wiki/Gene_dosage

Historical-sounding, maybe? It's still used in the literature:

https://www.nature.com/articles/s41467-022-32144-z

https://www.nature.com/articles/s41467-024-48960-4

https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/

[dekhn]

Yeah, when I saw the original comment I tried to find the source of the term but wasn't able to find it.

To me it sounds like medical genetics terminology (known for terms like "penetrance", "allele", "epistasis", "locus") whereas I'm a molecular biologist/biophysicist, which has far more precise ways of describing the underlying physical model.

[flobosg]

A term can be still used in literature for historical reasons. Both concepts are not mutually exclusive.

[kkylin]

And in yeast there has long been evidence for WGD. See, e.g., https://pmc.ncbi.nlm.nih.gov/articles/PMC4529243/ & references therein.

Edit: I posted this without looking at the paper (which is about yeast). Doh.

[flobosg]

In bacteria as well!