[vlovich123]

Rising co2 levels I believe are nowhere near the differential inside vs outside when windows are closed. There’s lots of reason to believe that rising co2 specifically lowers cognitive performance - our brains work on o2 and our body actively works to expel co2 as a waste product - increasing co2 levels means the body has less O2 available and has to work harder on co2 expulsion for survival instead of powering the brain.

[LorenPechtel]

Crowding out O2 isn't going to be meaningful, the amount of CO2 is simply too small. If there's an effect it's from reducing the rate at which the body can expel the CO2.

If crowding out O2 was relevant why do I feel the same on our local mountain at 10,000'+ vs 0'- in Death Valley? To crowd out that much O2 with CO2 would be lethal. (That's not to say that my performance is the same. There's a big difference in the heart rate I can sustain.) What we feel is the CO2 level in our blood rising because it isn't diffusing into the lungs. Lowering O2 is only detectable with training and that's based on noting the symptoms of oxygen deficiency on brain function. (Such training is relevant in the world of aviation where it might give warning that you need to grab that oxygen mask. The average person will never encounter such conditions, nor have the resources at hand to make use of the knowledge even if they did realize it.)

[frognumber]

This is not quite correct.

1) CO2 levels have risen from under 300PPM in 1860 to over 400PPM right now -- by around 150PPM -- with a rise of about 25PPM per decade for the past four decades.

The difference in CO2 levels in my bedroom with windows open and closed is a couple hundred PPM (500-800ppm range in my bedroom, with windows open and closed, respectively). I can definitely feel a difference in performance if I don't let in fresh air. It's more than climate change (300ppm versus 150ppm range), but not big-O more, and climate change is on-track to get there in another few decades. Conference rooms might be over 1000ppm, but it still big-O similar.

2) CO2 levels are measured in parts-per-MILLION. That argument simply doesn't make sense. The atmosphere is 21% oxygen. Crowding out oxygen is simply not an issue. Critically, from personal experience, if I have some dry ice in a room, I generally don't suffer.

People run into problems when CO2 levels reach a out 5000 ppm over many hours. Even the most dense conference rooms don't hit that.

[vlovich123]

Here’s what Claude says.

1. Direct effects on brain physiology: When CO2 levels rise in the blood (hypercapnia), it causes vasodilation of cerebral blood vessels. While this initially increases blood flow, sustained elevation disrupts the brain's normal pH balance, affecting neural function.

2. Acid-base imbalance: Elevated CO2 in the blood forms carbonic acid, decreasing blood pH. This acidosis affects enzyme function, neurotransmitter activity, and neuronal excitability throughout the brain.

3. Oxygen displacement: While not typically reaching dangerous levels in standard indoor environments, higher CO2 concentrations can slightly reduce oxygen availability to brain tissues in enclosed spaces.

4. Inflammatory responses: Research suggests prolonged exposure to elevated CO2 may trigger low-grade neuroinflammatory responses, potentially impairing cognitive processes.

5. Disruption of neurotransmitter systems: CO2-induced acidosis appears to affect several neurotransmitter systems, particularly GABA and glutamate, which are critical for cognitive functions like attention, memory, and decision-making.

Studies have shown measurable cognitive effects at CO2 concentrations as low as 1,000 ppm, with more significant impairment at 2,500+ ppm - levels commonly found in poorly ventilated meeting rooms, classrooms, and offices.

As for indoor vs outdoor:

> Rising atmospheric CO2 levels from global warming don't pose the same cognitive risks as elevated indoor CO2. While indoor environments can reach 1,000-5,000+ ppm, causing measurable cognitive decline through mechanisms like acid-base imbalance and neurotransmitter disruption, global atmospheric CO2 is only about 420 ppm. Even with projected increases to 500-1,000 ppm by 2100 in worst-case scenarios, these levels remain below thresholds for significant cognitive impairment. Our bodies can also better adapt to gradual atmospheric changes compared to rapid indoor CO2 accumulation, making climate change impacts the primary concern rather than direct cognitive effects.