Hacker News new | ask | show | jobs
by kpfleger 449 days ago
Nonesense. It's well established that dietary D3 (or D2, but D3 is better) clearly incleases 25(OH)D serum levels. It is that serum biomarker whose deficiency (levels below 20ng/ml or 30ng/ml) that has the largest association with higher risk of dozens of diseases as well as all-cause mortality. You can defend your phrasing by saying that "not well" just means one has to take a lot of it. Yes, there is a wide variety of dose response, which is why it's best to test blood levels to titrate supplementation amount.
1 comments

Is the blood level diagnostically significant with vit D? Or is this something like magnesium where serum levels can be normal while having a magnesium shortage? IIRC vit d is fat soluble, does the body store any excess quickly, or does it linger around?
Yes, from https://pmc.ncbi.nlm.nih.gov/articles/PMC5577589/

  The goal of this study was to investigate whether the relationship between body composition, serum 25-hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. ... In summary, although OB had significantly greater total vitamin D stores than C, the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the OM and SQ fat compartments was similar.