[TechDebtDevin]

Interesting, and thank you for the informative response. I have very weird reactions to cholinergic/anticholinergic drugs ranging from severe hallucinations to massive impacts to working memory. I've always figured there is something unique about that part of my biology but don't really no where to look to try and identify why.

[johnisgood]

I have weird or controversial reactions to most medications, especially psychiatric and drugs. I have no clue why. I have MS, I have brain lesions, they might play a part.

- For example nothing happened from 190 x 1 mg alprazolam + 0.5 L whiskey.

- None of the psychiatric medications worked for me (tried almost all there is, it took a long time). No pros, nor cons.

- Opiates do not cause euphoria, nor sedation for me. Without tolerance.

- The list goes on...

I have never figured out why medications affect me extremely differently from other people.

I took 5 x 50 mg DPH, nothing happened, then the next day I took it again, and I got anticholinergic toxicity. Perhaps it accumulated in this case, but yeah, it was one of the worst experiences I have had (delirium with dysphoric hallucinations, cognitive decline, memory issues). Took me months to recover. I have had auditory hallucinations for a couple of days, too.

What cholinergics and anticholinergics have you tried and what were your experiences?