[Fokamul]

Nope, cannot be done like this. You can block just some of the ADs on websites. But for example YouTube requests for video chunks, is same domain as ADs. So you would have Youtube with ADs.

Much easier solution, which everyone should made years ago, STOP using Chrome crapbrowser.

[TekMol]

For same-domain ads you could use content-inspection. That is probably how in-browser adblockers do it too.