[nisegami]

So it sounds like: 1. consuming aspartame triggers insulin release (unclear if this is novel information) 2. insulin release triggers inflammation that leads to atherosclerosis (they go into further detail on the mechanism here, which appears to be novel info)

It really doesn't seem to me like the artificial sweeteners should be the critical aspect of this finding, as this affects anything that triggers insulin release. Is there any data linking sulfonylureas with atherosclerosis? Based on this finding, one might expect that to be a consequence of their insulin releasing effect.

[elhudy]

I didn’t read the entire article and i am not a physician.

That said, your point #2 sounds incorrect - aspartame doesn’t cause atherosclerosis, it aggravates atherosclerosis. The key difference there as it relates to type 2 diabetes patients is that presumably if they had atherosclerosis as an existing condition, they would qualify for a glp-1 with cvd benefits, and not be on sulfonylureas in the first place.