[Sunspark]

B-vitamins are water soluble..

I take 50mg a day in a bio-available form pyridoxal-5-phosphate. Consider this form instead.

I'm taking it because there is some genetic evidence that I would benefit from doing so. No neuropathies thus far but it's only been about a month and a half.

[DavidPiper]

I wasn't even aware I was ingesting B6, I was just taking the tablets for the magnesium (it was one of the few with the full 440mg dose I was recommended).

Blood tests since then have shown that my B6 levels are fine with my usual diet, I don't take multivitamins or supplements anymore.

I don't know much about B6 beyond my own experiences with it, so all I can say is make sure you've discussed it with your GP, and be aware of the coasting effect if you do happen to develop any neuropathic symptoms: https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome

[Sunspark]

I have to admit I am troubled by reading all this including that it has a half-life.. I did have the assumption that water soluble meant that excess was eliminated out the same day as is the case with some things. I had literally never heard of this toxicity issue till last night. One problem in general is that supplements don't really come in a "smaller size" unless I guess, you get powder form instead of capsules. I will have to review the genetic data I have again.

Genetic data is useful to know really, especially for people with MTHFR mutations as many pathways get affected.