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by pfisherman 483 days ago
Another problem with measuring effectiveness that you are relying on patient (or caregiver) reported outcomes. There are no “objective” measurable criteria for depression, such as a biomarker on some lab test or survival at 5 years. Depression is assessed by asking people questions about how they feel, which is prone to all kinds of noise and bias.

A lot of the problem with studying psychiatric disorders is that you can’t just go around biopsying people’s brains; so we don’t have much of any idea what is going on at a molecular or cellular level. We just kind of know the behavioral tics that doctors can observe and what patients can tell us.