I've been on Qulipta (a CGRP drug) daily for about a year now. It started working pretty much immediately, and I cannot think of a single side-effect in use, other than that you will have a withdrawal period pretty much immediately if you miss a dose.
Before that I've used Rizatriptan to treat rather than prevent (works well, but can cause brain fog, mood swings and GI issues). In order to get approval for the CGRP I had to try lower-cost drugs like Verapamil (a calcium channel blocker) which had no effects at all, positive or negative, and Topiramate, which is the single worst medication I've ever used. Compared to all of those, the CGRP is a miracle and has been life-changing.
There a some small side-effects with Quilipta. I was a bit low energy for a couple a weeks until my body got used to it. Also, it is a mild appetite suppressant. I seem to be able to miss doses of a day or two just fine though. Nurtec also works well for me as an accute migrate treatment.
I'm on Emgality, and haven't noticed any side effects at all.
Honestly the worst part of it has been getting special approval from insurance; sometimes they don't cover much of it but right now the manufacturer provides a savings card that brings it down to $35/month.
Before that I've used Rizatriptan to treat rather than prevent (works well, but can cause brain fog, mood swings and GI issues). In order to get approval for the CGRP I had to try lower-cost drugs like Verapamil (a calcium channel blocker) which had no effects at all, positive or negative, and Topiramate, which is the single worst medication I've ever used. Compared to all of those, the CGRP is a miracle and has been life-changing.