[herniatedeel]

I get that fluoxetine, a relatively old SSRI is a dirty drug, but aren't newer serotonin modulators much cleaner? E.g., vilazodone, vortioxetine, and even old-fashioned Escitalopram (lexapro)?

My understanding is that escitalopram has pretty low binding affinity for other receptors than SERT.

[spoonfeeder006]

But serotonin is active in many aspects of the body's physiology no? So just because it may not act on other classes of receptors, it still has wide ranging impacts. There are many kinds of SERT receptors, as they mentioned, Fk isn't all that selective about it

[alsoforgotmypwd]

Fuck vilazadone and vortioxetine with 500kV. That shit gave me seizures, zaps, and myoclonus.

Fluoxetine made my mom murderously psychotic. Paroxetine gave me immediate serotonin syndrome.

The truth is most psychiatrists are unscientific shamans who don't measure or analyze the organ or systems they're supposedly treating.

The only thing I've found tolerable from more than a dozen medications has been mirtazapine. All SSRIs I've tried were of marginal benefit with terrible side-effects.

[AStonesThrow]

https://lyrics.lyricfind.com/lyrics/weird-al-yankovic-i-want...