wow I wasn't aware of VanJS before. It looks nice!
in my limited exploring of VanJS so far, I like that it also takes the direction to simplify things. That said, afaik VanJS simplifies the "JSX" part (so: we don't have to transpile from JSX to vanilla JS because... we don't even use JSX :D).
The first instructions in https://vanjs.org/start are for this.