[neom]

Not op but: dose response curves shown in their figures are quite smooth, and ceiling effect at exactly 100ug for positive effects with anxiety &ego dissolution continuing to increase linearly above that, some might read that as narratively convenient? I think it's a byproduct of it being 8:8 subjects in a well controlled setting, it's Liechti lab after all, they know what they are doing.

[killjoywashere]

Am op, sorry haven't had my coffee yet. Yeah, agree with noem. These curves would be smooth for a 3000-subject phase 3 trial. For 16 people? The error bars are even weirdly tight. One general truism: all the normals are the same, but abnormals are increasingly different in different ways. That gets more true as people get older, they just accumulate more varied life experience. Just looking at the participants section,

> "eight men and eight women; mean age ± SD: 29 ± 6.4 years; range: 25–52 years"

> "The participants were asked to consume no more than 10 standard alcoholic drinks/week and have no more than one drink on the day before the test sessions."

> "Drug administration timing did not consider the menstrual cycle in females for practical reasons. Four women used a hormonal contraceptive and one was menopausal."

> "Six participants had previously used LSD (1–3 times), eight participants had used methylenedioxymethamphetamine (MDMA) (1–5 times), ten participants had previously used a stimulant, including methylphenidate (four participants, 1–2 times), amphetamine (six participants, 1–3 times), and cocaine (two participants, 1–2 times), and one participant had smoked opium (once)."

These are not your standard young, male athletes you'd typically desire for a tightly controlled result.