[funnym0nk3y]

I wonder how that ties into the hyperconnectivity induced by various psychoactive substances like psilocybin.

All the research about GABA and glutamate seems too low level to me and not specific enough for treatment targets. Somewhat like using body weight to determine that disease.

[AnthonBerg]

I’d suggest tracing a line through the points of published research on autism, hyperthermia and its effects on autism spectrum related behaviors, the effect of Interleukin-17 thereon, the relationship from between IL-17 and Th17 helper cells, and the 5-HT2A receptor’s effects on Th17 cell regulation. And other stuff. Like thermoregulation. There’s more interesting stuff on the way and at every point.

To manage expectations: It’s… an imaginary line?

—- edit: on the run, hope to be able to follow up with papers

[galuggus]

does hyperthermia affect fungal infections? https://pmc.ncbi.nlm.nih.gov/articles/PMC7572136/

[AnthonBerg]

or vice versa, I have no idea!

I do recall reading that certain autoimmune disorders like psoriasis which are therapeutically impacted by serotonin receptors’ effects on the immune system do happen to increase susceptibility to fungal infection

iirc/afaik

before readings: that paper is wild

(I’ll approach it with a grain of salt while also not immediately discounting it)

[AnthonBerg]

I want to note that I am NOT making a connection to vaccines, nor do I see one. (Quite the opposite actually!)

[ddmf]

hmm - still feel autistic on psilocybin and other tryptamines but more aware (and it works like a reset switch), however I've never felt as normal (or more like the people around me) as I did that first summer I binged mdma - when I managed to stay awake that is...