For a person (my daughter) who has tried everything under sun (except ECT and psilocybin)for depression and OCD and nothing ever seemed to help, what is the latest on treatment horizon?
Psychedelics + cognitive therapy has a lot of promise. There's a lot of types of psychedelics and therapies to investigate. MDMA with a group of close friends/family in a safe and loving environment is probably the best you could do on your own.
Personally, cold exposure + lots of coffee + engaging work w/ others has been more effective than anything I've found in the healthcare system. Commit to daily work/social obligations, then drink enough coffee until you can will yourself to go everyday. Once it starts to become a habit is when my depression (slowly) will start to lift. If I stop for too long I fall back into the hole.
Have you considered any alternative explanations/diagnosis? Rates of misdiagnosis for psychiatric disorders are significant (even more so in women, anecdotally) and it could be the reason why the treatments aren't working. Depression can manifest as a consequence of untreated ADHD, for example.
Self-diagnosis is generally frowned upon but I think everyone owes it to themselves to at least try to find explanations that they can discuss with professionals.
we tried many avenues here as well
1.vitamin deficiency (she is vitamin D deficient, but it seems common in my race - asian 2. iron deficiency 3. gave magnesium for a while
4. someone diagnosed her for adhd and others disagreed 5. tested for autism. 6. tested for thyroid 7. took some T3/T4
Personally, cold exposure + lots of coffee + engaging work w/ others has been more effective than anything I've found in the healthcare system. Commit to daily work/social obligations, then drink enough coffee until you can will yourself to go everyday. Once it starts to become a habit is when my depression (slowly) will start to lift. If I stop for too long I fall back into the hole.