[DavidSJ]

I’m not sure I understand the process vs. initiation distinction you’re asking about, but yes I do believe there are other targets besides amyloid itself which make sense even if the amyloid hypothesis is true. Anything in the causal chain before or after amyloid but prior to neurodegeneration is a sensible target.

[Earw0rm]

Sure, I was just talking about a step in a feedback loop or degenerative spiral rather than whatever initiates the feedback loop in the first place.